The collection of about 850 items covers the period from 1782 to c. 1936, with the bulk dating to the 1780s to 1840s. The collection is divided into four series. Series I contains correspondence relating to a wide variety of topics, including French and English politics, business, trade, religious matters, and personal affairs. Many of the items are letters of introduction. There is also information on John Vaughan's immigration to America, Joseph Priestley, vaccines and inoculation (with Jefferson's comments on the same), Vaughan's business in Philadelphia, and the American Philosophical Society. Also included in this series are 2 boxes with copies of Vaughan correspondence as well as miscellaneous notes by E. W. Madeira, gathered in the course of his research on Vaughan in the 1930s. Series II consists of three volumes. Included are two of Vaughan's commonplace books. One, entitled, "J. Vaughan's book," May 17, 1779 (47 pp., in Latin; 870/L34), includes mostly Latin notations. The other commonplace book, dated 1783 (ca. 66 pp.; B V 462.c), includes comments on several prominent Americans, such as Benjamin Rush and David Rittenhouse, as well as American society generally. The third volume is a copybook with thirty letters spanning the period 1784 to 1801 (B V462.1). Series III includes material relating to Vaughan's administration of the estate of the Philadelphia merchant Samuel Merrick, 1796-1822 (Vaughan-Merrick Papers, B V462.m; 2 boxes). Series IV consists of correspondence between Vaughan and the DuPont Co. for which he served as agent (B V462.4; photocopies of 73 letters).

An extensive family collection, the Vaux Family Papers center around the lives of George Vaux V (1721-1803), George Vaux VII (1779-1836), and George Vaux VIII (1832-1915), their business partners, siblings, wives, and children, and encompasses the extended Vaux family of Warders, Sansoms, Heads, Graffs, Morrises, Cressons, and Mayberrys. The collection includes correspondence, financial accounts, receipts, business records, journals, diaries, photographs, and legal documents.

One of the oldest houses in Philadelphia, Wyck is now a non-profit museum listed on the National Register of Historic Places. Nine generations of the Jansen-Wistar-Haines family owned the Wyck property from 1690 until 1973. The last family owner deeded 2.5 acres of land, the house and its contents, several outbuildings, a landscaped garden, and a small endowment to the Wyck Charitable Trust. The Wyck Charitable Trust and the Wyck Association now administer the preservation of the property and its educational services to the public. This collection contains diaries, letters, accounts, bills and receipts, deeds, and photographs. The collection as a whole is deepest for the period 1770-1970. Items of particular note include accounts of household expenses at Wyck from ca. 1790-1970; papers pertaining to the Academy of Natural Sciences of Philadelphia, Quaker schools, and social reform groups; agricultural and horticultural practices; and correspondence to and from cultural leaders of 18th and 19th century Philadelphia. The papers of the John S. Haines family (Ms. Coll. 52A) form part of the Wyck Papers. The papers cover the years 1845 to 1949 and are arranged into eight series.

This is a collection of letters, letterbooks, account books, scrapbooks, etc., concerning the families of Robert Hare and Thomas Willing. The letters and other documents include early family material, as well as documents written by numerous family relations, and some obviously only collected by them. The Willing family letters (1744-1901) are diverse, concerning family matters, business, society, comments on the Civil War, etc. There are numerous letters from Thomas Willing, many concerning his banking career, as President of the Bank of North America and later at the first Bank of the U.S. The Hare family letters (1724-1965) are more extensive and diverse, including much on travel in the U.S. and elsewhere. There is a letter from Robert Hare Jr. concerning steam engines, and letters from Horace Binney Hare concerning his education at Harvard, 1860, his trip to San Francisco and the west, 1862, and numerous letters written while a soldier in the Civil War. There are many letters from Horace Binney (1780-1875, DAB) to his daughter Esther, who was married to John Innes Clark Hare (1816-1905, DAB), concerning family travel and court cases. There are also letters from outside the family, such as those from Dorothea L. Dix. The bound volumes include, among others: Robert Hare letterbooks (1824-1825, 1841-1857), estate records, and laboratory expense accounts (1818-1860); G. H. Hare's journal or log of cruises aboard the U.S. United States (1841) and U.S. Flint (1845); Horace Binney Hare's 1862 journal of his trip to San Francisco. There are account books and accounts (1754-1795) kept by Thomas Willing; accounts of the controversy over the estate of John Innes Clark; and records of the First Colored Wesley Methodist Church of Philadelphia (receipt book, 1820-1848; minute book, 1827-1844). There are also Philadelphia court records, and minutes of the Common Council of the city, 1832.

A collection of letters, legal papers and financial records of three generations of the prominent Philadelphia family. Spanning 1745-1955, detailed are the legal cases and political advocacy work of John Kintzing Kane (1795-1858), Robert Patterson Kane (1827-1906), and Francis Fisher Kane (1866-1955). Also includes correspondence, architectural drawings, and photograph albums of the Cope family. Robert Patterson Kane's daughter Eliza Middleton Kane (1863-1952) married the Philadelphia architect Walter Cope (1860-1902) in 1893. The APS papers of Elisha Kent Kane are in call no. B K132.